Diseases Surveillance
The rapid spreading of COVID-19 Delta variant has exposed the weakness in the surveillance capabilities of many countries. There is not only the need to further build up the internal capabilities, but also to facilitate collaboration among countries and organizations.
An important action is to strengthen laboratory and testing capacities. IOI has developed a robust and rapid samples tracking and laboratory reporting system that ensures accuracy and speed of result reporting. This facilitates timely identification of new cases and and limits the spread of clusters. A clinical trial management system is also built for infectious diseases screening platform.
IOI Diseases Surveillance Platform (IOIDSP)
1
Public Health Surveillance
IOI implemented a process management system to integrate all the robotic dispensers and analyzers. Data obtained are aggregated in a database for web based cohort studies.
2
Hybrid-AI to enable Clinical Decision Support
▪IOI collaborated with Singapore National University Hospital to develop a Symbolic AI based Diagnostic aid for identification of Temporal Mandibular Disease patients
▪The system manages patient session history, facilitate clinician examination, and apply rules/calculations to assist decision making in diagnosis and treatment of disease.
▪IOI will be adopting hybrid-AI approach for similar infectious diseases surveillance projects that have large datasets and that enables machine learning to find infected cases and tracking of the source.
3
Samples and Data Repository
At Tan Tock Seng Hospital, IOI implemented a web based histopathology database is to track ontological biopsy samples that are extracted from patients.
▪The System collect data and query aggregate data in a research friendly environment and for notification to the National Disease Cancer Registry.
▪Similar repositories have been developed on the cloud by IOI for other applications.
▪Depending on the use case, IOI will advise on the adoption of cloud or on-premise storage accordingly.
4
DNA Sequencing Portal
IOI is pleased to highlight that DNA Sequencing Management System has been operating a number of sequencers at Institute of Molecular and Cell Biology (IMCB) since 2008.
This is a web based system that allow 500 users to tap on the DNA Sequencing services at IMCB, including facilities for on-line submission of samples, monitoring of status of sequencing, and pulling of sequence results from the web.
Such systems generate DNA sequence data that are critical for downstream vaccines and diagnostic kits development.
5
Data Exchange Engine for Medical Record
IOI is the First in Asia to implement HL7 data exchange engine jointly with Singapore Ministry of Health and Hewlett Packard.
The system demonstrated how 4 hospitals can exchange medical records via on-the-fly conversion of record formats without changes in existing legacy system.
IOI aims to seek other similar standard compliant data exchange platforms to enable seamless integration and convergence of data among users and vendors.
6
Antibodies Production and Management System
IOI is pleased to highlight that DNA Sequencing Management System has been operating a number of sequencers at Institute of Molecular and Cell Biology (IMCB) since 2008.
This is a web based system that allow 500 users to tap on the DNA Sequencing services at IMCB, including facilities for on-line submission of samples, monitoring of status of sequencing, and pulling of sequence results from the web.
Such systems generate DNA sequence data that are critical for downstream vaccines and diagnostic kits development.
6
Manufacturing of DNA Microarrays
IOI worked with Singapore National Cancer Center to deliver the Automated Laboratory Information and Knowledge System for DNA Microarray Fabrication and Analysis.
One of the applications is to study the progression of breast cancer for Asian and Caucasian women.
The system provided best practices for manufacturing of DNA Microarrays
It seamless integrated analytical and data mining tools setup as intranet grid computing facility
7
Clinical Trials Management System
▪IOI provided the World first cloud based clinical trials system for National University Health System, Singapore Clinical Research Institute, Duke NUS and London Hospital to conduct a H1N1 clinical cohort study to evaluate the feasibility of replacing Tamiflu with Chloroquine
▪The project involved daily data collection of 1500 study subjects who are home based.
▪IOI contribution is acknowledged in the research findings published in The Lancet.
8
Global Disease Monitoring
▪A global portal was developed by IOI for deployment at Novartis Institute of Tropical Diseases for researchers and clinicians to monitor the technological progress made to counter Dengue.
▪This system provides live updates of information on the diseases, vectors, studies, news, etc. Restriction of access is implemented to control the sharing of clinical data.